INDOLE-BASED ALKALOIDS HAVE WIDE RANGE OF BIOLOGICAL ACTIVITIES, INCLUDING ANTITUMOR, ANTI-INFLAMMATORY, ANTIMICROBIAL, AND ANTIVIRAL ACTIVITIES

Indole alkaloids which are abundance in nature are a significant source of pharmacologically active compounds. Indole alkaloids have the potential to exert the anticancer activity via various ant proliferative mechanisms, and some of them such as Vinblastine and Vincristine have already used in clinic or under clinical evaluations for the treatment of cancers. Therefore, indole alkaloids occupy an important position in the discovery of novel anticancer agents. This review emphasizes the recent development of indole alkaloids as potential anticancer agents, their structure-activity relationship and mechanisms of action covering the articles published from 2015 to 2020. Key Words: Indole alkaloids, anticancer activity, ant proliferative mechanisms, clinical evaluations.