OSMI-4-based PROTACs do not influence O-GlcNAc transferase and O-GlcNAcylation levels in cells

The O-GlcNAc transferase (OGT) inhibitors disclosed thus far are burdened with certain shortcomings. We have incorporated OSMI-4, a nanomolar OGT inhibitor, into PROTACs. The prepared chimeras failed to induce effective OGT degradation or influence O-GlcNAcylation levels in MM.1S cells.

Publication Details

Journal
Repository of the University of Ljubljana (University of Ljubljana)
Published
2025-08-25
Primary Topic
Geochemistry and Geologic Mapping
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article
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article

OSMI-4-based PROTACs do not influence O-GlcNAc transferase and O-GlcNAcylation levels in cells

Repository of the University of Ljubljana (University of Ljubljana)
Geochemistry and Geologic Mapping
article

OSMI-4-based PROTACs do not influence O-GlcNAc transferase and O-GlcNAcylation levels in cells

article en

Abstract

The O-GlcNAc transferase (OGT) inhibitors disclosed thus far are burdened with certain shortcomings. We have incorporated OSMI-4, a nanomolar OGT inhibitor, into PROTACs. The prepared chimeras failed to induce effective OGT degradation or influence O-GlcNAcylation levels in MM.1S cells.

Repository of the University of Ljubljana (University of Ljubljana)
Openalex Percentile: Top 60%
Geochemistry and Geologic Mapping
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OSMI-4-based PROTACs do not influence O-GlcNAc transferase and O-GlcNAcylation levels in cells · Repository of the University of Ljubljana (University of Ljubljana) (2025) | TGRS Research Map | TGRS