Análisis de las Interacciones entre Inulina, Glucosa y Microbiota Intestinal: un Enfoque desde la Química Cuántica Aplicada

Inulin (INL) is a soluble, non-digestible fiber found in more than 36,000 plant species, primarily in vegetables such as onion, garlic, artichoke, and agave, among others, as a reserve polysaccharide. The molecules under study were constructed using HyperChem software. Quantum calculations were performed using the semiempirical SE-PM3 method, and the Polak–Ribiere conjugate gradient algorithm was used for geometric optimization to locate the state with the lowest formation energy. The results show that INL is primarily an oxidizing agent of amino acids (AAs) in the human body and is therefore a poor antioxidant. Comparative calculations and Morse curves indicate that excess glucose oxidizes INL. As a general conclusion, we find that inulin is blocked oxidatively by excess glucose.