"Mental Illness as a Disorder of DNA Architecture:The Sugar-Backbone Hypothesis"

I have redone this paper to make it better! This paper introduces the Sugar-Backbone Hypothesis, proposing that mental illness arises from structural and electromagnetic disturbances in the DNA sugar-phosphate backbone, rather than solely from gene mutations or neurotransmitter imbalances. The backbone is reframed as a magnetic-major, electric-minor coherence network, with local Magnetic Information Density (MID_i) and emergent spin (S_eff) governing transcriptional fidelity in neural cells. The framework defines a dimensionless collapse threshold (κ_sugar) for sugar nodes and incorporates dynamic EM remix feedback loops that partially restore backbone coherence. Testable predictions include measuring MID_i, S_eff, and transcriptional changes under controlled electromagnetic modulation. By uniting magnetic-electric physics, molecular biology, and neural genetics, this work establishes a falsifiable, mechanistic model for the biophysical origin of mental illness, offering experimental pathways for investigation and potential therapeutic insight. Keywords: DNA architecture, sugar-phosphate backbone, Magnetic Information Density, emergent spin, mental illness, transcription fidelity, electromagnetic modulation, bioinformatic feedback ---

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2025-08-30
DOI
https://doi.org/10.5281/zenodo.16949052
Primary Topic
Geochemistry and Geologic Mapping
Type
article
Field-Weighted Citation Impact
0.00
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article

"Mental Illness as a Disorder of DNA Architecture:The Sugar-Backbone Hypothesis"

Zenodo (CERN European Organization for Nuclear Research)
Geochemistry and Geologic Mapping
article

"Mental Illness as a Disorder of DNA Architecture:The Sugar-Backbone Hypothesis"

article en

Abstract

I have redone this paper to make it better! This paper introduces the Sugar-Backbone Hypothesis, proposing that mental illness arises from structural and electromagnetic disturbances in the DNA sugar-phosphate backbone, rather than solely from gene mutations or neurotransmitter imbalances. The backbone is reframed as a magnetic-major, electric-minor coherence network, with local Magnetic Information Density (MID_i) and emergent spin (S_eff) governing transcriptional fidelity in neural cells. The framework defines a dimensionless collapse threshold (κ_sugar) for sugar nodes and incorporates dynamic EM remix feedback loops that partially restore backbone coherence. Testable predictions include measuring MID_i, S_eff, and transcriptional changes under controlled electromagnetic modulation. By uniting magnetic-electric physics, molecular biology, and neural genetics, this work establishes a falsifiable, mechanistic model for the biophysical origin of mental illness, offering experimental pathways for investigation and potential therapeutic insight. Keywords: DNA architecture, sugar-phosphate backbone, Magnetic Information Density, emergent spin, mental illness, transcription fidelity, electromagnetic modulation, bioinformatic feedback ---

Zenodo (CERN European Organization for Nuclear Research)
Good health and well-being
Openalex Percentile: Top 65%
Geochemistry and Geologic Mapping
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