Impact des triazoles sur les cellules ovariennes de patientes et lien avec les eaux souterraines et les sols

Polycystic ovary syndrome (PCOS), often associated with obesity, is the main reproductive disorder inwomen of childbearing age. Two fungicides, Tebuconazole (Tb) and Epoxiconazole (Epox), are presentin soils and groundwater in the Centre Val de Loire region. We show that Epox and Tb reduce steroidsynthesis by human ovarian cells (hCG), probably via the nuclear receptor, AhR. Moreover, Tb is morecytotoxic than Epox on hCG. Finally, we found that Tb and Epox more strongly altered the ovarian cellsof PCOS and/or obese patients, suggesting that women with certain fertility and/or metabolic disordersare more sensitive to triazole exposure.