Evaluation intégrée des effets toxicologiques, écotoxicologiques et écologiquesde l’ensemble des traitements phytopharmaceutiques utilisés sur une saison culturale : exemple de la pomme de terre en Hauts-de-France

This project enabled a retrospective assessment of the effects related to the use of plant protectionproducts (PPP) during potato cultivation. In the field, cultivated soils presented multi-residualcontamination by low doses of PPP, which may be old, following the cultivation or treatments of nearbyplots; concerning tubers, few residues have been found, and at very low concentrations. In the laboratory,following oral exposures of mice, a transient, significant effect of PPP used for the cultivation and storageof harvested tubers on gene expression and much more reduced at the level of the intestinal microbiotawas observed. For exposures carried out in microcosms with cultivated soils, ecotoxicology models(earthworms, plants) expressed different responses, but few effects overall