A Review on Self Nanoemulsifying Drug Delivery System (SNEDDS)

<p><span>Self-nanoemulsifying drug delivery systems (SNEDDS) have emerged as a promising approach for improving the oral bioavailability of poorly water-soluble drugs, particularly those classified under Biopharmaceutics Classification System (BCS) Class II and IV. SNEDDS are isotropic mixtures of oils, surfactants, and co-surfactants that spontaneously form fine oil-in-water nanoemulsions upon mild agitation in gastrointestinal fluids. This unique property enhances drug solubilization, promotes faster dissolution, and facilitates lymphatic transport, thereby bypassing first-pass metabolism. Over the past decades, significant advancements have been made in the selection of excipients, optimization techniques, and characterization methods to ensure stability, efficacy, and patient compliance. SNEDDS offer advantages such as ease of manufacturing, scalability, and protection of labile drug molecules, yet challenges remain in drug precipitation control, in-vivo predictability, and regulatory standardization. This review highlights the formulation strategies, mechanistic insights, recent technological advancements, and potential clinical applications of SNEDDS, aiming to guide future research and industrial translation</span><span lang="EN-IN">.</span><span lang="EN-IN"> </span></p>