The Effects of High-Fat Diet on the Molecular Pathways in Cardiac Tissue: A Systematic Review of in vivo Rodent Studies and Integrated Bioinformatic Analysis

This systematic review aims to comprehensively evaluate the effects of high-fat diets on molecular pathways in cardiac tissue, focusing on evidence from in vivo rodent models. Rodents are frequently used to mimic human cardiometabolic conditions, providing mechanistic insights into how dietary fat influences cardiac physiology and pathology. The review synthesize data on transcriptomic, proteomic, and signaling pathway alterations induced by high-fat diet exposure.