Design, Synthesis, Characterisation and Biological Evaluation of Novel 7- Fluoroquinolone Derivatives

<p><span lang="EN">In the present study, a series of 1-ethyl-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-chloro-3-quinoline carboxylic acid substituted with phenyl thiourea at C-3, ethyl, cyclopropyl substitution at N-1 and piperazine, piperadine, morpholine, 1H-imidazole and 2-aminoethane thiol at C-7 position were synthesized and characterized by IR, 1H-NMR, mass spectral and elemental analysis. Biological profile like antibacterial activity against four different strains viz. Staphylococcus aureus, Staphylococcus epidermidis (gram positive bacteria), E. coli, Klebsiella pneumoniae (gram negative bacteria), Aspergillus niger and Aspergillus fumigatus (fungi) by paper disc method have been studied.</span></p>