Integrating Neuroaesthetic Design into Brain-on-Chip Research: Toward Enhanced Neural Engagement and Cognitive Accessibility

Abstract: This study examines the potential for neuroaesthetic design and adaptive neurofeedback principles to enhance brain-on-chip (BoC) research, with an emphasis on optimizing neural engagement and cognitive accessibility for diverse populations. Existing BoC platforms have transformed neuroscience through high-fidelity modeling of neural circuits, yet cognitive accessibility and sensory inclusion remain comparatively underexplored. Drawing upon recent studies in neuroinclusion, multisensory interface design, and adaptive feedback, this work synthesizes findings from biophilic interface architecture, neurofeedback literature, and embodied cognition frameworks. The manuscript outlines a multidisciplinary research agenda that prioritizes sensory diversity and ethical considerations in the evolution of BoC systems. Instead of making unverifiable or overgeneralized claims, the discussion focuses on plausible experimental approaches and mechanisms—such as AI-driven neurofeedback, real-time biofeedback, and personalized sensory modulation—supported by peer-reviewed evidence. Emphasis is placed on translational strategies to accommodate neurodivergent user groups, mitigate algorithmic bias, and foster inclusive neural interface development. By reimagining BoC systems through the lens of neuroaesthetic engagement, this article calls for a paradigm shift in the design and application of neurotechnology, encouraging the integration of scientifically grounded, accessible, and ethically responsible methodologies.