In-Silico Approach of T-Resveratrol as a Potential Alternative Therapy for Dementia

<p>Dementia, including Alzheimer’s disease (AD), is a neurodegenerative disorder characterized by progressive cognitive decline, neuronal dysfunction, and oxidative stress. Current pharmacological interventions offer limited symptomatic relief and are often associated with adverse effects. Natural compounds like T-resveratrol have been identified as viable alternatives as a result of theirmultifaceted neuroprotective properties. This research examines therapeutic potential of T-resveratrol against dementia-associated targets using an in-silico approach. Molecular docking, pharmacokinetic (ADMET) predictions, and molecular dynamics (MD) simulations were employed for assessing interaction of T-resveratrol with key pathological targets including acetylcholinesterase (AChE), beta-amyloid (Aβ) peptides, tau protein, and oxidative stress mediators. The results demonstrate strong binding affinities and favorable pharmacokinetic properties, indicating that T-resveratrol holds significant promise as an alternative therapeutic agent for dementia.</p>