Prodrug of 5-FU for cancer therapy

The activity of 5-FU is markedly limited by its rapid degradation into 5-FUH 2fluoro-5,6-dihydrouracil) via the action of the cytosolic enzyme DPD (Dihydro pyrimidinedehydrogenase),the first enzyme in the catabolic cycle of 5 -FU. It has been demonstrated that this enzymedeactivates more than 85% of the injected dose of 5-FU. Little drug is thus left for anabolism. Thisencourages the need of prodrug of 5 F-U.

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2025-01-01
DOI
https://doi.org/10.5281/zenodo.16927114
Primary Topic
Geochemistry and Geologic Mapping
Type
article
Field-Weighted Citation Impact
0.00
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article

Prodrug of 5-FU for cancer therapy

Zenodo (CERN European Organization for Nuclear Research)
Geochemistry and Geologic Mapping
article

Prodrug of 5-FU for cancer therapy

article en

Abstract

The activity of 5-FU is markedly limited by its rapid degradation into 5-FUH 2fluoro-5,6-dihydrouracil) via the action of the cytosolic enzyme DPD (Dihydro pyrimidinedehydrogenase),the first enzyme in the catabolic cycle of 5 -FU. It has been demonstrated that this enzymedeactivates more than 85% of the injected dose of 5-FU. Little drug is thus left for anabolism. Thisencourages the need of prodrug of 5 F-U.

Zenodo (CERN European Organization for Nuclear Research)
Good health and well-being
Openalex Percentile: Top 68%
Geochemistry and Geologic Mapping
DOIOpen Access PDFOpenAlex
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Prodrug of 5-FU for cancer therapy · Zenodo (CERN European Organization for Nuclear Research) (2025) | TGRS Research Map | TGRS