Histopathological Grading of Leukoplkia: A Review

AbstractLeukoplakia, a which is a common oral potential malignant lesion, often preceding into the development of oral carcinoma. Clinically, it typically appears as whitish patches on the oral mucosa. Despite advancements in diagnostic tools, histopathological grading remains the gold standard for evaluating such lesions, primarily by identifying characteristics of epithelial dysplasia a pre-malignant alteration marked by specific cellular & architectural changes.However, grading leukoplakia histologically presents significant challenges for oral & diagnostic pathologists, including inter- & intra-observer variability & ambiguity in selecting the extremely relevant diagnostic criteria. To enhance consistency & accuracy, it is essential that pathologists adopt standardized grading protocols & clearly defined criteria when interpreting dysplasia in leukoplakia. This article provides a concise overview of the various histopathological grading systems currently used for assessing leukoplakia.