Oral Hyaluronic Acid (400 kDa Acid / 240 mg/day)

Abstract Hyaluronic acid (HA) is a principal natural oral nutria-cosmetics moisturizing factor in skin and a volumetric component of the dermal extracellular matrix (ECM). Age-related declines in HA drive dryness, laxity, and fine lines. Medium-molecular weight HA around 400 kDa offers the best balance of oral bioavailability and functional stability: it is absorbed (paracellular route), appears in plasma within hours, and distributes to the dermis where it engages CD44 receptors, stimulating endogenous HA, collagen, and elastin synthesis. Clinically, 120-240 mg/day improves stratum-corneum hydration, elasticity, and skin texture while lowering TEWL within 6-8 weeks; 240 mg/day represents a high-efficacy, well-tolerated dose below EFSA’s 480 mg/day upper level. In multi-ingredient systems, HA synergizes with Ceramide NP (lipid-barrier reinforcement / TEWL reduction), elastin peptides (elastic matrix support), nicotinamide (NMF / ceramide upregulation and tone modulation), and vitamin C (antioxidant and collagen cofactor), together delivering visible hydration, firmness, wrinkle attenuation, and barrier resilience.