Prodrug of 5-FU for cancer therapy

The activity of 5-FU is markedly limited by its rapid degradation into 5-FUH 2fluoro-5,6-dihydrouracil) via the action of the cytosolic enzyme DPD (Dihydro pyrimidinedehydrogenase),the first enzyme in the catabolic cycle of 5 -FU. It has been demonstrated that this enzymedeactivates more than 85% of the injected dose of 5-FU. Little drug is thus left for anabolism. Thisencourages the need of prodrug of 5 F-U.

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2025-01-01
DOI
https://doi.org/10.5281/zenodo.16926839
Primary Topic
Prenatal Screening and Diagnostics
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Prodrug of 5-FU for cancer therapy

Zenodo (CERN European Organization for Nuclear Research)
Prenatal Screening and Diagnostics
article

Prodrug of 5-FU for cancer therapy

article en

Abstract

The activity of 5-FU is markedly limited by its rapid degradation into 5-FUH 2fluoro-5,6-dihydrouracil) via the action of the cytosolic enzyme DPD (Dihydro pyrimidinedehydrogenase),the first enzyme in the catabolic cycle of 5 -FU. It has been demonstrated that this enzymedeactivates more than 85% of the injected dose of 5-FU. Little drug is thus left for anabolism. Thisencourages the need of prodrug of 5 F-U.

Zenodo (CERN European Organization for Nuclear Research)
Good health and well-being
Openalex Percentile: Top 32%
Prenatal Screening and Diagnostics
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Prodrug of 5-FU for cancer therapy · Zenodo (CERN European Organization for Nuclear Research) (2025) | TGRS Research Map | TGRS