Integration of the Green Analytical Chemistry (GAC) Principles and Quality-By-Design (QBD) Steps for Sustainable Analytical Methods: A Systematic Review

Since its inception, Green Chemistry has focused on the necessity of removing or reducing the detrimental impact that different organic solvents have on the environment and human health. Analytical methods typically jeopardize two crucial factors: environmental impact and safety. The dual goals of being robust and ecologically benign can be achieved in a single way by utilizing the principles of Quality by Design (QbD) and Green Chemistry. The significance and benefits of employing both Green analytical chemistry and QbD in analytical methods are covered in this paper. In pharmaceutical analysis, QbD is a methodical and meticulous approach to method development. It places a strong emphasis on thoroughly assessing and methodically investigating alternate approaches in order to achieve the greatest possible method performance. More green chemistry concepts, such reducing waste, conserving energy and materials, and integrating analytical measures into extensive quality-control procedures, will eventually be incorporated into the production of chemicals. Quality by Design (QbD) in that particular industry is in line with the application of green chemistry concepts to analytical chemistry. A review of the incorporation of green analytical techniques into QbD is presented in this work.