Clinical wound healing activity of Terminalia arjuna bark extract gel in goats

The experiment was conducted to evaluate the efficacy of a gel prepared from ethanolic bark extract of Terminalia arjuna on clinical cases of goats having wound presented to Veterinary clinical complex of College of Veterinary and Animal Sciences, MAFSU, Parbhani. 5% ethanolic bark extracted gel of Terminalia arjuna was formulated and was topically applied for assessing acute dermal toxicity on Wistar rats. Results revealed that 2000 mg/kg body weight is a safe dose as there were no any altered behavioral change and clinical reaction observed. Also on histopathological examination didn’t show any toxicity related histoarchitectural changes in any of the organ of Wistar rats. After assessing the acute dermal toxicity of Terminalia arjuna gel formulation, its wound healing efficiency is tested on goats. 12 cases of goats with wound were selected and divided into 2 groups as group A and group B, treated topically with Povidone iodine solution and gel prepared from ethanolic bark extract of Terminalia arjuna respectively. The evaluation of gel for wound healing was done with monitoring the visual parameters (swelling, colour, pain, irritation, exudation and percent wound contraction) at day 0, day 7, day 14, day 21 and day 28 after/ till healing and hemato-biochemical parameters on day 0 and day 14 after treatment from both the groups were estimated. The result found that gel prepared from Terminalia arjuna has rapid rate of wound healing by reducing swelling, pain, irritation and exudation fastly, and the speed of wound contraction in group treated with Terminalia arjuna gel slightly faster than group treated with povidone iodine. The hemato-biochemical analysis revealed all observations were found in normal physiological range in both the groups. The T. arjuna gel was found safe for topical application and also promotes the rate of wound healing.