Epigenetic Reprogramming of Fibroblasts Drives Tumor Immunosuppression

Major Finding: NNMT-expressing cancer-associated fibroblasts recruit suppressive monocytes that inhibit CD8+ T cells, promoting tumor growth.Concept: NNMT epigenetically reprograms cancer-associated fibroblasts, upregulating complement factors that drive tumor immune suppression.Impact: Targeting NNMT offers a therapeutic strategy to reprogram the tumor microenvironment and enhance immunotherapy outcomes.

Publication Details

Journal
Cancer Discovery
Published
2025-01-01
DOI
https://doi.org/10.1158/2159-8290.cd-rw2025-075
Primary Topic
Geochemistry and Geologic Mapping
Type
article
Field-Weighted Citation Impact
0.00
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article

Epigenetic Reprogramming of Fibroblasts Drives Tumor Immunosuppression

Cancer Discovery
Geochemistry and Geologic Mapping
article

Epigenetic Reprogramming of Fibroblasts Drives Tumor Immunosuppression

article en

Abstract

Major Finding: NNMT-expressing cancer-associated fibroblasts recruit suppressive monocytes that inhibit CD8+ T cells, promoting tumor growth.Concept: NNMT epigenetically reprograms cancer-associated fibroblasts, upregulating complement factors that drive tumor immune suppression.Impact: Targeting NNMT offers a therapeutic strategy to reprogram the tumor microenvironment and enhance immunotherapy outcomes.

Cancer Discovery
Openalex Percentile: Top 70%
Geochemistry and Geologic Mapping
DOISourceOpenAlex
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