Photocatalytic E → Z Isomerization of gem-Bromofluoroalkenes: Stereoselective Synthesis of β-Fluorostyrene Derivatives

Stereoselective synthesis of β-fluorostyrene derivatives has been achieved. Selective isomerization of gem-bromofluoroalkenyl benzenes bearing various ortho-substituents is enabled by using Ir photocatalysts with high triplet energy. Subsequent one-pot transition-metal (TM)-catalyzed reactions enable pot-economical synthesis of monofluoroalkenes in a stereoselective manner.