Self-Bubbling Hydrogel for Uti: A Novel Solution with Amoxicillin and Corn Silk

<p><span>Urinary tract infection are among most common bacterial infection affecting individuel worldwide The present study focuses on the formulation and evaluation of a novel floating hydrogel system embedded with self-gererating micro-Bubbles for the efficient delivery of Amoxicillin Trihydrate Combined with natural therapeutic benefits of corn silk extract. The hydrogel system aim to enhance<span>   </span>gastric retention time and improve localized delivery and bioavailability of drug at infection site. The incorporation. of microbubbles facilitates buoyancy and sustained release, while corn Silk Provide additional anti-inflammatory and diuretic effects. Comprehensive evaluation was carried out through physicochemical characterization, Swelling index, viscosity, drug release, MIC Test. The Presence of micro bubbles improved the internal Porosity and release kinetic, while corn sick extract contributed to an additional layer of therapeutic benefit. In conclusion, the formulated floating hydrogel system represents a promising approach for improving management of uti by combining<span>  </span>the advantages gastroretentive delivery, natural adjunct of<span>  </span>therapy, and controlled antibiotic release.This system could potentially reduce dosing<span>  </span>frequency, enhance patient compliance. Urinary tract infections (UTIs) are a prevalent health concern globally, often requiring prolonged antibiotic therapy that may lead to systemic side effects and reduced patient compliance. This study aims to develop and evaluate a novel floating hydrogel system incorporating Amoxicillin trihydrate and corn silk (Zea mays) extract for targeted, sustained, and synergistic treatment of UTIs.<span>   </span></span></p>