ΔG → J/s² Resonance-Band Model — Prospective SARS-CoV-2 Validation (Feb 2025 Sequences)

Description:This release documents the first prospective validation of the ΔG → J/s² resonance-band codon model on novel SARS-CoV-2 sequences published on 28 Feb 2025, well after the model’s development lock-date. Key findings: Resonance-band codons (0.1933–0.3866 J/s²) enriched ~1.4× vs. random codon background (p ≈ 0.016). Clustering patterns and stop-codon insertions mirrored COSMIC cancer and VDJdb immune repertoires. Confirms cross-domain generalisability and early-signal predictive power. Package contents: Python script to compute codon J/s² values, banding, and enrichment. Metadata CSV of Feb 2025 SARS-CoV-2 genome fragments. README with ΔG → J/s² equation and usage instructions. License (CC-BY 4.0) and citation metadata. This dataset and code confirm that the Codon Sentience framework prospectively identifies mutation hotspots across cancer, immune, and viral contexts, supporting operational readiness for future pathogen monitoring.