Formulation and Evaluation of Oro-Dental Gel

<p><span lang="EN">The objective of the present work was to develop and evaluate an oro-dental gel for targeted management of oral pain and inflammation. Ketorolac tromethamine, a potent NSAID, was selected as the primary drug and combined with herbal actives Acacia catechu (Khadira) and clove oil to enhance therapeutic efficacy and patient compliance. Gels were prepared using suitable gelling agents and evaluated for physicochemical parameters including appearance, pH, homogeneity, spreadability, extrudability, swelling index, viscosity, drug content, and in vitro drug release. FTIR compatibility studies confirmed no significant drug–excipient interactions. The optimized formulation exhibited acceptable pH, good spreadability, and excellent extrudability, with sustained release following diffusion-controlled kinetics. The combination of synthetic and herbal components offered synergistic anti-inflammatory and analgesic activity while minimizing systemic side effects. The results suggest that the formulated oro-dental gel is a promising, patient-friendly dosage form for localized therapy in various oral inflammatory conditions.</span></p>