FORMULATION AND EVALUATION OF PINAVERIUM COLON TABLETS

<div> <p><em><span>Pinaverium bromide (INN) is a medication used for functional gastrointestinal disorders. It belongs to a drug group called antispasmodics and acts as a calcium channel blocker in helping to restore the normal contraction process of the bowel. It is most effective when taken for a full course of treatment and is not designed for immediate symptom relief or sporadic, intermittent use. In the present research work sustained release matrix formulation of Pinaverium<span>    </span>targeted to colon by using various polymers developed. </span></em><em><span>To achieve pH-independent drug release of Pinaverium, pH modifying agents (buffering agents) were used. Colon targeted tablets were prepared in two steps. Initially core tablets were prepared and then the tablets were coated by using different pH dependent polymers. Ethyl cellulose, Eudragit RLPO and L100 were used as enteric coating polymers. The precompression blend of all formulations was subjected to various flow property tests and all the formulations were passed the tests. The tablets were coated by using polymers and the coated tablets were subjected to various evaluation techniques. The tablets were passed all the tests. Among all the formulations F5 formulation was found to be optimized as it was retarded the drug release up to 18 hours and showed maximum of 98.19% drug release. It followed higuchi kinetics mechanism.</span></em></p> <p><strong><em><span>Keywords: </span></em></strong><em><span>Pinaverium, Colon targeted drug delivery system, Ethyl cellulose, Eudragit RLPO, Eudragit L 100</span></em></p> </div>