A STUDY ON MACRO CYCLICAL SYNTHESIS AND CLASSIFICATION OF ALICYCLIC LIGANDS AND BIOLOGICAL ACTIVITIES

<p><span>The metal complexes of the Schiff base were pivotal in the development of coordination chemistry.<br>Various Schiff base complexes have been extensively researched due to their antibacterial, anticancer,<br>analgesic, anti-inflammatory, antifertility, and herbicidal properties. The chelating ligands with donor<br>atoms N, N, and O have a wide range of biological activities and are of particular interest because they<br>connect to metal ions. It is well known that the presence of metal ions bound to physiologically active<br>substances increases their activity. Although numerous Schiff bases have been explored as ligands<br>utilizing salicylaldehyde and modified salicylaldehydes and amines, no work has been done on the<br>essential nucleus of Schiff bases salicylaldehyde and 2- aminobenzimidazole. The Schiff base metal<br>complexes have been widely explored for their commercial and biological uses. 2- aminobenzimidazole<br>complexes with different metal ions have been synthesized, physicochemically characterized, and<br>biologically active. This article focuses on porphyrins, a ubiquitous family of macrocyclic chemicals that<br>play critical roles in various biological processes, including the absorption of solar energy<br>(photosynthesis) in plants and the delivery of oxygen in animals.</span> </p>