Вірус папіломи людини – етіологічний чинник гігантської кондиломи Бушке – Левенштейна (Клінічний випадок)

Human papillomavirus (HPV) has more than 100 different genotypes, which are the cause of a significant number of diseases – benign, precancerous lesions and various types of cancer. One of the clinical manifestations of papillomavirus infection is giant condyloma acuminata, also called Buschke–Lowenshtein tumor. Of all reported penile tumors in the United States, giant condyloma Buschke-Lowenshtein (GCBL) accounts for approximately 5 to 24%. Despite its benign histology, GCBL is clinically malignant due to its locally destructive nature with extensive involvement of underlying tissue, high rate of local recurrence, and ability to spread to the pelvic organs, which will subsequently require surgical intervention.A feature of this clinical case is that the patient had simultaneous infection with HPV types 11, 16 and 40, and the papillomavirus infection occurred in the form of GCBL. This diagnosis was confirmed by virology and pathomorphology. By the way, more than 9 months passed from the moment of the onset of the disease and the patient’s appeal to doctors for help to the verification of the diagnosis. During this time, the disease progressed, and the treatment tactics already required surgical intervention in several stages.Different routes of infection, high contagiousness of HPV, oncogenic properties of the pathogen, lack of etiotropic medications dictate the need, along with the search for effective treatment methods, to actively introduce vaccine prophylaxis for this pathology. The use of the Gardasil 9-valent vaccine (provided that the vaccination schedule is followed) stimulates a strong humoral response, the production of type-specific virus-neutralizing antibodies and minimizes the risk of HPV infection and the oncological pathology caused by it. The description of this clinical case will increase the awareness of healthcare professionals about the course of papillomavirus infection and will contribute to the appointment of vaccination as the only means capable of protecting against HPV infection at the present stage.