Antibiotic Detection Technology Based on Molecularly Imprinted Polymer Sensors

Molecularly imprinted polymer (MIP) sensors, as an emerging molecular recognition technology, demonstrate tremendous application potential in the field of antibiotic detection. Using tetracycline as the research target, molecularly imprinted polymers with high selectivity were prepared using precipitation polymerization method, and an electrochemical sensor detection system was constructed. The sensor achieved a detection limit of 0.5 ng/mL for tetracycline, with a linear range of 1-1000 ng/mL, a selectivity factor of 6.6, and exhibited good stability and reproducibility. Compared with traditional HPLC-MS/MS methods, the detection time was reduced from 2-3 hours to 15 minutes, with costs reduced by more than 85%. This technology was successfully applied to the detection of tetracycline residues in milk, meat, and environmental water samples, and the detection capability for other antibiotics was validated, providing an effective technical means for food safety monitoring and environmental pollution assessment.