PREPARATION AND CHARACTERIZATION OF FLOATING DRUG DELIVERY SYSTEM OF TELMISARTAN

In this study, the gastro retentive floating drug delivery system for the hypertension medication Telmisartan, which is made from HPMC and sodium alginate, will be developed and evaluated. assessed for in vitro buoyancy, swelling, dissolution, and release mechanism, as well as physico-chemical characteristics. Based on the buoyancy and dissolving tests, F 9 was chosen as the best formulation. There was a non-Fickian diffusion mechanism and zero order rate kinetics in the optimised formulation. When FTIR tests were used to characterise the optimised formulation, no drug-polymer interaction was found. Keywords: Telmisartan, Sodium Alginate, Sodium Bicarbonate, Calcium Carbonate