FORMULATION AND OPTIMIZATION OF PERINDOPRIL ERBUMINE FAST-DISSOLVING ORODISPERSIBLE TABLETS

The present study aimed to formulate and evaluate orodispersible tablets (ODTs) of Perindopril Erbumine using natural, synthetic, and co-processed superdisintegrants to enhance disintegration, dissolution, stability and bioavailability. Perindopril Erbumine, an ACE inhibitor with limited oral bioavailability (40–45%) and a half-life of 5–10 hours, is used in the treatment of hypertension and cardiovascular conditions. ODTs were prepared via direct compression using Irbesartan as active ingredient, HPMC, Eudragit L 100, Aspartame, Ethyl cellulose, Dimethyl sulfoxide, Propylene glycol, Ethanol and superdisintegrants such as Moringa oleifera, Crospovidone, and Croscarmellose, including co-processed blends (1:1 ratios) at concentrations of 10% and 15%. FTIR studies confirmed no drug–excipient interactions. Pre-compression and post-compression evaluations indicated good flow properties and acceptable physical characteristics. Among all formulations, F7 (Moringa oleifera and Crospovidone, 1:1 at 10%) demonstrated optimal performance with the shortest disintegration time (21 sec), wetting time (27 sec), and highest drug release (99.5% at 30 minutes). This study highlights the potential of natural-synthetic co-processed superdisintegrants in developing effective orodispersible formulations.