When Severe Hypothyroidism Mimics Neuromuscular Diseases: A Case Supporting Outpatient Management in Modern Endocrinology

A 40-year-old man presented to the emergency department with postural instability, diplopia, myalgia, and elevated creatine kinase, initially suggesting a neuromuscular or acute neurological disorder. Laboratory tests revealed severe hypothyroidism (TSH >170 μU/mL, suppressed fT4). Despite the marked biochemical abnormalities, his clinical stability allowed safe outpatient management with levothyroxine and endocrinology follow-up. This case, which mimicked inflammatory myopathy or brainstem stroke, illustrates that hypothyroidism can manifest with neurological signs and emphasizes the need to consider endocrine causes in the differential diagnosis. It also supports the safety and effectiveness of structured outpatient pathways for clinically stable hypothyroid patients.

Publication Details

Journal
Figshare
Published
2025-01-01
DOI
https://doi.org/10.6084/m9.figshare.29926865.v2
Primary Topic
Theoretical and Computational Physics
Type
article
Field-Weighted Citation Impact
0.00
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article

When Severe Hypothyroidism Mimics Neuromuscular Diseases: A Case Supporting Outpatient Management in Modern Endocrinology

Figshare
Theoretical and Computational Physics
article

When Severe Hypothyroidism Mimics Neuromuscular Diseases: A Case Supporting Outpatient Management in Modern Endocrinology

article en

Abstract

A 40-year-old man presented to the emergency department with postural instability, diplopia, myalgia, and elevated creatine kinase, initially suggesting a neuromuscular or acute neurological disorder. Laboratory tests revealed severe hypothyroidism (TSH >170 μU/mL, suppressed fT4). Despite the marked biochemical abnormalities, his clinical stability allowed safe outpatient management with levothyroxine and endocrinology follow-up. This case, which mimicked inflammatory myopathy or brainstem stroke, illustrates that hypothyroidism can manifest with neurological signs and emphasizes the need to consider endocrine causes in the differential diagnosis. It also supports the safety and effectiveness of structured outpatient pathways for clinically stable hypothyroid patients.

Figshare
Openalex Percentile: Top 57%
Theoretical and Computational Physics
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