Additional file 3 of Co-prescribing of antidepressants and opioids for non-cancer pain in England, 2010–2019: a descriptive study using CPRD primary care electronic health records

Additional file 3. Table S3.1. Table. Characteristics of prevalence cohort by co-prescription length, aged 18-100 years, England 2010–2019. Table S3.2. Median and interquartile range (IQR) of co-prescription length in days, overall and by characteristics for all co-prescriptions and those lasting at least 90 days. Fig. S3.1. UpSet plot showing the most commonly co-prescribed opioids and antidepressants with at least 14 days overlap, individually and in combination. Fig. S3.2. UpSet plot showing the most commonly co-prescribed opioids and antidepressants with at least 28 days overlap, individually and in combination. Fig. S3.3. UpSet plot showing the most commonly co-prescribed opioids and antidepressants with at least 365 days overlap, individually and in combination. Fig. S3.4. Length of prevalent co-prescribing of the most common medicine combinations, in days, up to 365+ days. Fig. S3.5. Incidence rates of opioid and antidepressant co-prescribing per 1000 person years over time in adults aged 18-100 years, 2010-20019, England; a) overall and by sex, b) by age group, c) by Townsend deprivation quintile, d) by ethnic group. Fig. S3.6. Comparison of original and sensitivity populations over time for a) prevalence and b) incidence of opioid and antidepressant co-prescribing.