Situação vacinal e desfecho clínico da COVID-19 em pacientes hospitalizados

Objective: to analyze the relationship between the vaccination status of patients hospitalized for COVID-19 and clinical outcomes. Methods: retrospective cohort study conducted at a referral hospital for COVID-19, including 305 patients ≥ 5 years of age admitted to wards and/or intensive care units with a diagnosis of COVID-19. Hospitalization data were collected from electronic medical records, and vaccination status data were obtained from the VaciVida system. The analysis was performed using Poisson regression models. Results: the comparison between patients who did not receive any vaccine doses and those who received a booster dose showed a relative risk of 1.46 (p = 0.160), suggesting an increased risk of death among the unvaccinated; however, this was not statistically significant. The comparison between unvaccinated individuals and those with an incomplete vaccination schedule revealed a relative risk of 2.42 (p = 0.350). Conclusion: it was observed that most patients who died or required intensive care did not have a complete vaccination schedule, which points to a possible trend toward worse outcomes among unvaccinated individuals. Contributions to practice: the findings underscore the importance of vaccination and active surveillance of clinical factors associated with severity to inform management in patients with COVID-19.