PF4-associated immune thrombocytopenia and thrombosis (PITT)—More than heparin and vaccines

A young woman presented with portal vein thrombosis and thrombocytopenia and developed further extensive thrombosis following treatment with heparin. Despite no previous heparin exposure, she was found to be strongly positive for anti-platelet factor 4 (PF4) antibodies. She had acute cytomegalovirus (CMV) infection and a monoclonal gammopathy. Commentary on: Nicolson et al. Anti-PF4 mediated thrombocytopenia and thrombosis associated with acute cytomegalovirus infection displays both HIT-like and VITT-like characteristics. Br J Haematol 2025 (Online ahead of print). doi: 10.1111/bjh.20092.

Publication Details

Journal
White Rose Research Online (University of Leeds, The University of Sheffield, University of York)
Published
2025-06-01
Primary Topic
Diverse Scientific and Economic Studies
Type
article
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article

PF4-associated immune thrombocytopenia and thrombosis (PITT)—More than heparin and vaccines

White Rose Research Online (University of Leeds, The University of Sheffield, University of York)
Diverse Scientific and Economic Studies
article

PF4-associated immune thrombocytopenia and thrombosis (PITT)—More than heparin and vaccines

article en

Abstract

A young woman presented with portal vein thrombosis and thrombocytopenia and developed further extensive thrombosis following treatment with heparin. Despite no previous heparin exposure, she was found to be strongly positive for anti-platelet factor 4 (PF4) antibodies. She had acute cytomegalovirus (CMV) infection and a monoclonal gammopathy. Commentary on: Nicolson et al. Anti-PF4 mediated thrombocytopenia and thrombosis associated with acute cytomegalovirus infection displays both HIT-like and VITT-like characteristics. Br J Haematol 2025 (Online ahead of print). doi: 10.1111/bjh.20092.

White Rose Research Online (University of Leeds, The University of Sheffield, University of York)
Good health and well-being
Openalex Percentile: Top 38%
Diverse Scientific and Economic Studies
OpenAlex
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PF4-associated immune thrombocytopenia and thrombosis (PITT)—More than heparin and vaccines · White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (2025) | TGRS Research Map | TGRS