Association of serum 25-hydroxyvitamin D concentrations and myopia in the U.S. Population — Results from the NHANES 2001-2008

Abstract Background: myopia is associated with sight-threatening potential complications, and it becoming increasingly common globally. However, the association between serum 25-hydroxyvitamin D [25(OH)D] concentrations and myopia remains unclear and the evidence is controversial. Thus, this study aimed to investigate the association between serum 25(OH)D concentrations and myopia in the U.S. population. Subject and methods: this study used the National Health and Nutrition Examination Survey (NHANES) 2001-2008 data. The logistic regression was applied to explore the association between serum 25(OH)D concentrations and myopia. Results: among the 14,051 participants, the prevalence of myopia was 33.2 % (4,668/14,051). In the multivariate regression models, serum 25(OH)D concentrations as continuous variable were non-significantly associated with the prevalence of myopia (adjusted OR, 0.98 [95 % CI, 0.97-1.00]) after adjusting all covariates. As a categorical variable, serum 25(OH)D compared with the lowest tertile, the adjusted ORs with increasing tertiles were 0.96 (95 %CI: 0.89,1.05) and 0.95 (95 %CI: 0.86, 1.06). In myopia participants, serum 25(OH)D concentrations were also non-significantly associated with the progress of myopia. In stratified analyses, the results remain stable with different ages, sex, and education parameters. Conclusions: serum 25(OH)D concentrations were non-significantly associated with myopia in the U.S. population. We need more prospective studies to provide evidence.