Антимікробні властивості новосинтезованих арил ациклічних аміноспиртів щодо клінічних штамів ентерококів

Objective. The present work is devoted to the in vitro antimicrobial activity of newly synthesized aryl acyclic amino alcohols, namely, derivatives of alkyl (R-aryl) oxydialkyl ammonium salts against clinical strains of enterococci. Materials and methods. The object of the study was 52 newly synthesized aryl acyclic amino alcohols, namely derivatives of quaternary salts of alkyl(aryloxyethoxy)dialkylaminopropanol, synthesized at the Institute of Organic Chemistry of the National Academy of Sciences of Ukraine. The antimicrobial activity was evaluated in vitro by agar diffusion and serial dilutions against the reference strain Enterococcus faecalis ATCC 29212 and 25 clinical isolates. The efficacy of the compounds against clinical strains was evaluated by comparison with the activity of antimicrobial drugs. Results. As a result of the screening against the reference strain, the compounds with the most pronounced antienterococcal activity were identified. The most active ones (Kc21, Kc14, Kc28, Kc13, Kp13) had retention zones of more than 14 mm. The MIC determination identified 10 most active compounds, the MIC of Kp10 and Kp19 against the reference strain was 0.58 ± 0.10 μg/ml and 1.76 ± 0.19 μg/ml. As for clinical strains, the compounds showed moderate activity, with MIC values ranging from 0.48 to 15.63 μg/ml, inhibiting a proportion of isolates at the level of ampicillin and vancomycin. All compounds outperformed the activity of tetracycline in inhibiting antibiotic-resistant strains. The antimicrobial effect of the studied substances was at the level of decamethoxin and significantly exceeded the activity of miramistin. Conclusions. The study made it possible to identify the 10 most active compounds against the test microorganisms and to compare them with commercial antimicrobial drugs. The list of the most effective aryl acyclic amino alcohols is presented in the following list: Kp10, Kp19, Kp8, Kc2, Kp18, Kc23 Kc1, Kc3, Kc4, and Kc22. The data obtained indicate the prospects for further study of the antimicrobial properties of alkyl (R-aryl) oxydialkyl ammonium derivatives