Розувастатин: від ліпідознижувальних та плейотропних ефектів до впливу на серцево-судинну смертність

Statins are the basis of treatment of dyslipidemia, which is one of the key risk factors for the development of atherosclerosis and its complications, in particular ischemic heart disease (IHD) and stroke. The article highlights the pharmacodynamics and mechanism of action of statins, their clinical efficacy and effect on the lipid profile. The results of the largest studies that studied the effect of rosuvastatin on endothelial dysfunction, its pleiotropic, anti-inflammatory and antioxidant effects, antiproliferative and antifibrotic effects are described. The effect of statins, in particular rosuvastatin, on the cardiovascular system and blood pressure, their antithrombotic effect and effect on the progression of atherosclerosis are described. The importance of bioavailability and efficacy of generic drugs, in particular Romestin, which is a more affordable alternative to the original drug, is emphasized.