Synthesis of Potential Therapeutic Methods for Mycetoma

Mycetoma is a deadly disease that most commonly affects areas that are unable to obtain treatment for it in time. It is most often caused by a fungus called Madurella mycetomatis, but it can also be caused by bacteria called actinomycetoma or fungi called eumycetoma. The most common location for mycetoma is usually on the foot, with it usually affecting males between 11 and 40 years of age. The most common areas where mycetoma is reported are India, Mexico, and Sudan. There is currently a need for a cheaper and more effective therapeutic for mycetoma. The Drugs for Neglected Diseases initiative (DNDi) is dedicated to addressing tropical diseases like mycetoma. DNDi's Open Synthesis Network collaboratively develops drugs with universities and other organizations. My project synthesizes derivatives of the hit compound DNDI0003105207 in OSN Project 4, with modifications to the structure. The synthesized compounds will be sent to DNDi structure-activity relationship (SAR) studies. The data collected will help in developing a lead therapeutic for mycetoma.