The Role of Ubiquitin-Proteasome System (UPS) in Asthma Pathology

Shuzhou Deng,1,2 Le Ding,1,3 Yisong Qian,1 Xuan Huang1 1The National Engineering Research Center for Bioengineering Drugs and the Technologies, Jiangxi Provincial Laboratory of Bioengineering Drugs, Institute of Translational Medicine, Jiangxi Medical College, Nanchang University, Nanchang, People’s Republic of China; 2The Queen Mary School, Jiangxi Medical College, Nanchang University, Nanchang, People’s Republic of China; 3School of Pharmacy, Jiangxi Medical College, Nanchang University, Nanchang, People’s Republic of ChinaCorrespondence: Xuan Huang, The National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Jiangxi Medical College, Nanchang University, Nanchang, People’s Republic of China, Email [email protected]: Asthma represents a major global health concern, underscoring an imperative for further exploration into its pathogenesis to inform the development of more effective treatment strategies. As a key mechanism for intracellular protein degradation and regulation, the ubiquitin-proteasome system (UPS) plays a crucial but complex and multifaceted role in the pathological process of asthma. This study systematically reviews the functions and mechanisms of E3 ubiquitin ligases and deubiquitinases within the UPS in asthma. The study explores the impact of these mechanisms on the occurrence of inflammation and the alteration of airway hyperresponsiveness by regulating the synthesis and release of inflammatory factors, as well as the proliferation or differentiation of key inflammatory cells. A comprehensive understanding of the pathological mechanism of UPS in asthma will help to provide new theoretical basis and potential drug targets for the precision treatment, which holds great promise for the treatment of asthma in the future.Keywords: UPS, asthma, E3 ubiquitin ligase, deubiquitinases