The Role of NLRP3 Inflammasome in Oral Squamous Cell Carcinoma

Rui Shi,1,2 Xuan Zhuang,3 Tong Liu,4 Song-nan Yao,3 Feng-shan Xue3 1Department of Oral and Maxillofacial Reconstruction, The Affiliated Hospital of Qingdao University 266600, Qingdao, 266555, People’s Republic of China; 2School of Stomatology of Qingdao University, Qingdao, 266555, People’s Republic of China; 3Cardiac Surgery Intensive Care Unit Department, the Affiliated Hospital of Qingdao University, Qingdao, 266555, People’s Republic of China; 4The Affiliated Tai’an City Central Hospital of Qingdao University, Taian, 271000, People’s Republic of ChinaCorrespondence: Song-nan Yao, Cardiac Surgery Intensive Care Unit Department of the affiliated hospital of Qingdao University 266600, Qingdao, People’s Republic of China, Email [email protected] Feng-shan Xue, Cardiac Surgery Intensive Care Unit Department of the affiliated hospital of Qingdao University 266600, Qingdao, People’s Republic of China, Email [email protected]: Oral squamous cell carcinoma (OSCC) is the most common malignant tumor in the head and neck. More and more evidence emphasizes the importance of inflammation in the progression of OSCC. The main signaling pathway of acute and chronic inflammation consists of the activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome.Objective: This review focuses on the role of NLRP3 immune kinase body and giving a contribution to the development of new treatment strategies against OSCC.Conclusion: The NLRP3 inflammasome plays a vital role in the pathogenesis and development of OSCC and may serve as a promising therapeutic target for autoimmune diseases.Keywords: NLRP31, oral squamous cell carcinoma 2, Caspase-13, GSDMD4, autophagy5