Progressive Weight Loss-Induced Remission of Insulin Resistance/Hyperinsulinemia and Improvements in Cardiovascular Risk Factors

Mingxin Leng,1 Xiaoxuan Guo,2 Chongyang Wei,1 Yanju Zhang,3 Zhouhuiling Li,3 Xinying Gao,3 Dangmin Hou,3 Chunjun Li1,4 1Graduate School, Tianjin Medical University, Tianjin, People’s Republic of China; 2School of Medicine, Nankai University, Tianjin, People’s Republic of China; 3Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, People’s Republic of China; 4Health Management Center, Tianjin Union Medical Center, Nankai University Affiliated Hospital, Tianjin, People’s Republic of ChinaCorrespondence: Chunjun Li, Health Management Center, Tianjin Union Medical Center, Nankai University Affiliated Hospital, No. 190 of Jieyuan Road, Hongqiao District, Tianjin, People’s Republic of China, Tel +86-22-13752090635, Email [email protected]: Hyperinsulinemia (HI) is a common endocrine metabolic disorder in obesity and is closely associated with cardiovascular disease.Aim: This study aims to investigate the effects of progressive weight reduction on HI and cardiovascular risk factors.Methods: We enrolled 68 patients with overweight or obesity. Body composition assessments, clinical indicator sampling and a 75g-oral glucose tolerance test were conducted at baseline and after 12-month weight loss to assess HI and insulin sensitivity. And the people were divided into four groups based on the percent of weight loss (< 10%, ~20%, ~30%, > 30%) to study the remission of HI and changes in body composition and cardiovascular risk factors.Results: A total of 66 participants were studied at the end. Progressive weight loss significantly reduced plasma glucose and insulin (P< 0.001, P for trend< 0.001) and did not progressively reduce cardiovascular risk factors (P for trend< 0.001). The greater the percentage of weight loss, the greater the remission rate of insulin resistance and hyperinsulinemia (P for trend< 0.001), which reaches 100% when weight loss exceeds 30%. After adjusting for factors such as age, gender, and medication usage, remission of HI was still associated with progressive weight loss.Conclusion: With progressive weight loss, people with overweight or obesity experienced further improvements in glycemic outcomes, body compositions, HI and insulin resistance.Keywords: hyperinsulinemia, obesity, Insulin resistance, weight loss, body composition