The impact of Western diet and binge alcohol consumption on kidney oxidative stress

Diet and alcohol consumption play a significant role in oxidative stress levels, which can negatively impact kidney function. This study evaluates the effects of a Western diet and binge ethanol consumption on kidney health. C57BL/6J mice (n=6-7 mice/sex/group) were assigned to control, control/binge, Western diet, or Western/Binge groups for 12 weeks. Analysis of malondialdehyde (MDA) levels, a marker of oxidative stress, showed Western diet increased MDA regardless of alcohol. Serum blood urea nitrogen and creatinine levels did not show significant differences. These findings suggest that diet and alcohol intake increase kidney oxidative damage.