Human In Vitro Modeling of Traumatic Brain Injury

Traumatic brain injury (TBI) has been the leading cause of disability and death in young people, and there has been a search for a fitting model to understand the effects of trauma on the brain. To develop a TBI in vitro model that utilizes brain organoids, I utilized resin-based 3D printing to print a model and test how this model works on brain organoids. This research can provide an alternative to the current model to acquire and analyze data from brain organoids when traumatized (which delivers uniform displacement). Currently, I am analyzing the model’s performance using MATLAB to process recorded images and assess displacement, ensuring the model's reliability in simulating trauma.