El aumento de la masa grasa corporal se vincula a un cociente respiratorio alto en personas con mal nutrición por exceso

Introduction: Obesity is a global pandemic associated with a higher risk of non-communicable chronic diseases and increased overall mortality. It is characterized by an excess of subcutane-ous and visceral adipose tissue. Visceral adipose tissue plays a keyrole in energy regulation; an imbalance in substrate availability may reflect mitochondrial dysfunction. In individuals with obesity, cellular alterations in adipose tissue have been observed, contributing to a reduced capacity for fatty acid oxidation a phenomenon known as metabolic inflexibility.Objective: To analyze metabolic profiles in adults with overweight and obesity through resting indirect calorimetry and its relationship with fat and muscle mass. Methodology: Adults with normal weight, overweight, and obesity were evaluated in the Exer-cise Physiology Laboratory at Universidad Santo Tomás, Santiago campus. Anthropometric measurements (four skinfolds) and resting indirect calorimetry were recorded. The analysis included respiratory quotient (RQ), percentage of fat mass, and muscle mass. Results:Participants with obesity exhibited a higher resting RQ compared to individuals with normal weight. This finding was associated with a higher percentage of fat mass and lower rel-ative muscle mass. Conclusions:The results suggest that obesity is associated with metabolic inflexibility, evi-denced by a reduced capacity to oxidize fats at rest. This phenomenon may be related to mito-chondrial dysfunction, insulin resistance, and chronic inflammation.