A Comprehensive Review of Stem Cell Conditioned Media Role for Anti-Aging on Skin

Ayatulloh Alquraisy,1 Gofarana Wilar,2 Ahmed Fouad Abdelwahab Mohammed,3 Ali El-Rayyes,4 Cecep Suhandi,1 Nasrul Wathoni1 1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Padjadjaran, Sumedang, 45363, Indonesia; 2Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, University of Padjadjaran, Sumedang, 45363, Indonesia; 3Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt; 4Department of Chemistry, College of Science, Northern Border University, Arar, Saudi ArabiaCorrespondence: Nasrul Wathoni, Email [email protected]: Various studies have been widely conducted on conditioned medium for the development of anti-aging preparations, including the utilization of stem cells, which present a promising alternative solution. This narrative review aims to understand the latest developments in various conditioned medium stem cell applications for anti-aging on the skin. A search of the Scopus database yielded publications of interest. The research focused on articles published without restrictions on the year. After finding 68 articles in the search results, they moved on to the checking phase. Upon comprehensive literature review, 23 articles met the inclusion criteria, while 45 articles were deemed ineligible for participation in this research. The results of the review indicate that conditioned medium from various stem cells has demonstrated success in reducing risk factors for skin aging, as proven in various tests. The successful reduction of the risk of skin aging has been established in vitro, in vivo, and in clinical trials. Given the numerous studies on the progress of exploring and utilizing conditioned medium, it is expected to provide a solution to the problem of skin aging.Keywords: conditioned medium, stem cell, anti-aging, skin aging