Chlorzoxazone-Induced Fixed Drug Eruption: A Clinical Case Report

Hend Alotaibi,1 Reem Alsergani,1 Amer Abdulaziz Alharbi,1 Khalid Nabil Nagshabandi,1 Asma Ahmed Almubark2 1Department of Dermatology, College of Medicine, King Saud University, Riyadh, Saudi Arabia; 2College of Medicine, King Faisal University, Al-Ahsa, Saudi ArabiaCorrespondence: Khalid Nabil Nagshabandi, Department of Dermatology, College of Medicine, King Saud University, PJ7C+89Q, Riyadh, 12372, Saudi Arabia, Tel +966-582940888, Email [email protected]: Fixed drug eruptions (FDEs) are dermatological manifestations characterized by recurrent lesions at the same site upon re-exposure to the causative drug. We present a novel case of a 32-year-old female who developed bilateral symmetrical erythematous papules on her thighs following the use of chlorzoxazone for chronic back pain. This case is particularly significant as it underscores the potential for this specific drug, which is commonly prescribed, to induce FDE—a reaction previously unreported in the literature. The findings emphasize the necessity for clinicians to maintain a high index of suspicion for drug-induced skin reactions, even with medications considered safe and routinely used. This case serves as a critical reminder of the importance of thorough medication history assessments and the potential implications of drug interactions in dermatological care.Keywords: acetaminophen, chlorzoxazone, drug-induced fixed eruption, pain management, paracetamol, skin hypersensitivity, symmetrical skin lesions