CircRNA Networks in CAD: Multi-Cellular Mechanisms and Clinical Potential

Huan Cheng,1 Xinyu Wu,2 Jingru Li,1 Luqiao Wang1 1Department of Cardiology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650032, People’s Republic of China; 2Department of Cardiology, Zhumadian City Central Hospital, Zhumadian, Henan, 463000, People’s Republic of ChinaCorrespondence: Luqiao Wang, Department of Cardiology, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650032, People’s Republic of China, Tel +86-15887099143, Email [email protected]: Coronary artery disease (CAD), is a global cardiovascular disease that is characterized by myocardial ischemia and hypoxia caused by coronary artery occlusion. Circular RNAs (CircRNAs) is a particular kind of endogenous non-coding RNA, which can affect the occurrence and development of CAD. Concurrently, several circRNAs display stable persistence in CAD patients, attributable to their exceptional exonuclease resistance, thereby harboring the capacity to evolve into a biomarker for CAD diagnosis and prognosis. This article endeavors to clarify the pivotal role of circRNAs in the intricate pathophysiological processes underlying CAD patients or CAD disease models based on their unique biological characteristics and functionalities, and further discuss their prospects in clinical applications of CAD.Keywords: anti-nuclease activity, endothelial cells, vascular smooth muscle cells; myocardial cells; cardiac fibroblasts, diagnostic biomarkers