Clinical Maternal and Neonatal Features in COVID-19 Infected Pregnancies in Tianjin, China

Yan Liu,* Shuai Li,* Rong Liu Department of Obstetrics and Gynecology, Tianjin First Central Hospital, Nankai University, Tianjin, 300192, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yan Liu, Department of Obstetrics and Gynecology, Tianjin First Central Hospital, Nankai University, No. 24 Fukang Road Nankai District, Tianjin, 300192, People’s Republic of China, Email [email protected]; [email protected]: Outbreak of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic, leading to over 6 million deaths worldwide. Pregnant women suffer from a higher risk facing the pandemic COVID-19, while their related clinical information is limited.Methods: The clinical information of SARS-CoV-2 positive (n = 30) and negative pregnant women (n = 134) in Tianjin First Central Hospital (from November 30, 2022, to January 20, 2023) were collected. All statistical analyses were conducted in R language, employing t test or Chi-square test methods.Results: Significantly higher heart rate, temperature, and intrapartum hemorrhage were observed in positive pregnant women, besides fetal placentation grading, umbilical cord around the neck, cardiac B-scan ultrasound, and ultrasonic examination of lower limb vessels were significantly differential between positive and negative individuals. As for coagulation test, significantly higher activated partial thromboplastin time (APTT), Thrombin Time (TT), and D-dimer (DD2) were found in SARS-CoV-2 positive patients. Liver function test results indicated that six indicators were significantly differential between positive and negative individuals.Conclusion: Compared to negative pregnant women, significantly abnormal liver function and coagulopathy were observed in positive patients. As the unique vulnerable population, SARS-CoV-2 infected pregnant women should be payed more attention in clinical practice.Keywords: COVID-19, pregnant women, clinical feature, coagulopathy