Assessing Functional Changes in the Gut Microbiome in CTCL Patients Pre- and Post Therapy

The human microbiome, composed of bacteria, fungi, and viruses, is influenced by diet, health, and the environment, impacting immune response, digestion, and mental health. This study analyzed microbiome data from CTCL patients, focusing on changes after phototherapy. Using Microbiome Analyst, we identified 32 significant enzymes and 8 pathways. Notably, enzyme EC:1.1.1.370 and pathway P562 increased post-phototherapy, indicating metabolic shifts in inositol processing. These findings suggest phototherapy may modulate microbial metabolism, warranting further research.