Association and Diagnostic Value of TyG-BMI for Hyperuricemia in Patients with Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study

Haitao Li,1 Ge Gao,1 Zhikai Xu,1 Lihua Zhao,1 Yuling Xing,2 Jianqiu He,3 Yu Gao3 1Graduate School of Chengde Medical University, Chengde, 067000, People’s Republic of China; 2Department of Endocrinology, Hebei General Hospital, Shijiazhuang, 050017, People’s Republic of China; 3Department of Endocrinology, Affiliated Hospital of Chengde Medical University, Hebei Key Laboratory of Panvascular Diseases, Chengde, 067000, People’s Republic of ChinaCorrespondence: Yu Gao, Department of Endocrinology, Affiliated Hospital of Chengde Medical University, Hebei Key Laboratory of Panvascular Diseases, Chengde, 067000, People’s Republic of China, Tel +86 15633142973, Email [email protected]: This study aimed to investigate the association between TyG-BMI and hyperuricemia in NAFLD patients and assess its potential diagnostic value compared to the TyG index.Patients and Methods: This study selected the patients diagnosed with fatty liver disease at the Affiliated Hospital of Chengde Medical University between September and December 2023. These patients were divided into NAFLD without HUA (NAFLD-NUA, n=1166) and NAFLD with HUA (NAFLD-HUA, n=844) groups. Baseline characteristics between the groups were compared. Patients were divided into quartiles (Q1–Q4) according to their TyG-BMI level; the lowest quartile (Q1) was used as the reference group. Multivariate logistic regression analysis was used to investigate the association between TyG-BMI and HUA. Receiver operating characteristics curve analysis and area under the curve (AUC) were used to evaluate the diagnostic accuracy.Results: Patients in the NAFLD-HUA group had higher levels of TyG-BMI than patients in the NAFLD-NUA group(252.45± 34.11VS 234.34± 31.88, P< 0.001). Pearson correlation analysis showed that TyG-BMI levels were positively correlated with serum uric acid (SUA) (r=0.309, P< 0.001). After adjusting for potential confounders, logistic regression analysis revealed that TyG-BMI was a risk factor for HUA(OR:1.019 95% CI:(1.012, 1.027).) and shows superior diagnostic accuracy (AUC: 0.656) compared to the TyG index (AUC: 0.605).Conclusion: TyG-BMI index is a risk factor for HUA in patients with NAFLD, and demonstrates acceptable diagnostic accuracy for NAFLD-HUA. But further prospective studies are needed to confirm these findings.Keywords: triglyceride glucose-body mass index, hyperuricemia, non-alcoholic fatty liver disease, insulin resistance, metabolic syndrome