The Application of microRNAs in Papillary Thyroid Cancer: A Bibliometric and Visualized Analysis

Tinghua Zhang,1 Bo Yuan,2 Shaofu Yu3 1Department of Clinical Laboratory, the Second People’s Hospital of Huaihua City, Huaihua, Hunan, People’s Republic of China; 2Department of Clinical Laboratory, Southern University of Science and Technology Hospital, Guangdong, Shenzhen, People’s Republic of China; 3Department of Clinical Pharmacy, the Second People’s Hospital of Huaihua, Huaihua, Hunan, People’s Republic of ChinaCorrespondence: Shaofu Yu, Department of Clinical Pharmacy, the Second People’s Hospital of Huaihua, Huaihua, Hunan, People’s Republic of China, Tel +86-13974531958, Email [email protected]: Thyroid cancer is the most common malignant endocrine tumor, with papillary thyroid carcinoma (PTC) being the most prevalent type, accounting for 85% of thyroid cancer cases. Here, we conducted a bibliometric analysis of the literature in the field of microRNAs in PTC research to demonstrate current trends and research hotspots, and present a visual map of past and emerging trends.Methods: We searched the Web of Scientific Core Collection (WoSCC) database for publications from 1999 to 2023 centered on this field. Next, we employed visualization tools such as VOSviewer, CiteSpace, and Microsoft Excel 2019 to present co-occurrence and co-citation analyses, trends, hotspots, and visual representations of contributions from authors, institutions, journals, and countries/regions.Results: The bibliometric analysis encompassed the period from 1999 to 2023, with 994 papers from 54 countries/regions. The country with the most publications and highest total citations was the People’s Republic of China, but the United States held the highest average citation rate. Among the top ten productive institutions, the Ohio State University (Ohio State Univ) was the most prominent contributor to this field. The JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (J Clin Endocrinol Metab) ranked first in terms of citation counts and average citations among the top ten productive journals. In terms of keywords, “circular RNAs”, “promotes”, and “progression” have become prominent research areas.Conclusion: This study elucidates current trends, hotspots, and emerging frontiers in miRNA research within PTC, and provides new insights and guidance for future identification of new PTC biomarkers and clinical trials.Keywords: microRNAs, papillary thyroid cancer, bibliometric, VOSviewer, CiteSpace