Unveiling the Network regulatory mechanism of ncRNAs on the Ferroptosis Pathway: Implications for Preeclampsia

Yuan Zhang,1,2,* Jingjing Zhang,3,* Sirui Chen,1 Mianxin Li,1,4 Jin Yang,1,2 Jingsi Tan,1 Binsheng He,1,* Lemei Zhu1,4,* 1Hunan Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations, Changsha 410219, People’s Republic of China; 2School of Stomatology, Changsha Medical University, Changsha 410219, People’s Republic of China; 3Department of Gynaecology and Obstetrics, Hunan Provincial Maternal and Child Health Hospital, Changsha 410219, People’s Republic of China; 4School of Public Health, Changsha Medical University, Changsha 410219, People’s Republic of China*These authors contributed equally to this workCorrespondence: Binsheng He; Lemei Zhu, Hunan Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations, Leifeng Road 1501, Wangcheng District, Changsha, 410219, Chnia, Tel +86 731– 88602602, Email [email protected]; [email protected]: Non-coding RNAs (ncRNAs) are transcripts originating from the genome that do not serve as templates for protein synthesis. They function as epigenetic and translational regulators in various pathophysiological mechanisms, including cell proliferation and apoptosis. The ferroptosis signaling pathway, a novel mode of cell death, participates in numerous pathophysiological processes. Its signaling transmission is both complex and precise, featuring interconnected and interdependent pathways. Recent studies suggest that ncRNAs can finely regulate key genes in the ferroptosis pathway, thus modulating cellular functions, reducing oxidative stress, and maintaining maternal-fetal interface homeostasis. Future strategies targeting the ncRNA/ferroptosis axis may provide new perspectives and potential intervention points for treating preeclampsia. This article clarifies how the ncRNA/ferroptosis axis impacts preeclampsia, revealing how ncRNAs interact with ferroptosis, and pinpointing new molecular targets for the treatment of preeclampsia, thereby providing theoretical support for clinical strategies.Keywords: preeclampsia, non-coding RNAs, ferroptosis, network regulation, treatment strategies